The Open Targets Platform is a freely available resource for the integration of genetics, omics and chemical data to aid systematic drug target identification and prioritisation. The Platform provides summaries of the evidence (e.g. germline variants, somatic mutations, pathways, drugs) for the involvement of a specific gene with a selected disease. It supports disease and target centric workflows, displays the evidence for target-disease associations, as well as profiles of relevant target and disease annotations. The Platform is open-source with the data available for download and the code available on GitHub. Please see Carvalho-Silva et al. 2019 for more information on the Platform features and scoring methodologies.
The Platform assists with target identification and prioritisation by scoring target-disease associations based on our data sources. Our association score ranges from 0 to 1, the latter represents the strongest association, and it is calculated based on the confidence levels in the evidence.
To start using the Platform, you can search for a disease name, a gene name or symbol, or a protein name or symbol. You can also search for synonyms and abbreviations of genes (e.g. p53) and diseases (e.g. AD for Alzheimers disease) and Ensembl or EFO IDs (e.g. ENSG00000091831).
The Open Targets Platform Core Team is an experienced group of individuals with specialised skills in bioinformatics, computer science, web development, user experience design, and scientific outreach and training.
Scientific Outreach Lead
User Experience Design Lead