The Open Targets team at our 10 year anniversary celebration in October 2024
Join our team!
Open Targets is based on the stunning Wellcome Genome Campus, home to some of the world's foremost institutes and organisations in genomics and computational biology. We work in dynamic teams at the interface of academic and pharma industry science on a crucial problem, how to be more successful in making drugs. Working with us, you will be exposed to new technologies and a dynamic set of scientists dedicated to translational research.
Our posts are usually in either one of our academic partners, The Wellcome Sanger Institute or EMBL-EBI and have terms and conditions associated with the employer.
Important note: applications may be reviewed on an ongoing basis and the advertised post(s) may be filled before the stated deadline.
Postdoctoral Research Associate/Fellow - Genomic Data Science/Bioinformatics
Application closing date: 1 December 2025
This post is based at the University of Exeter.
Join a project to study immune response in neurodegenerative disease, as part of a large-scale collaborative research project involving, among others, the University of Exeter, Open Targets, the Wellcome Sanger Institute, EMBL-EBI, and the University of Oxford. The project aims to optimise and utilise cellular model systems, gene editing, and single-cell transcriptomic and spatial approaches to better understand immune responses in neurodegeneration.
Postdoctoral fellow - Petsalaki Group - NetworkCommons
Application closing date: 17 December 2025
Help create an open, community-driven platform that transforms how researchers interpret biological networks and identify new therapeutic targets.
You will benchmark and integrate state-of-the-art network contextualisation methods, combining large-scale transcriptomics, proteomics, and single-cell data across key disease areas including oncology, inflammatory bowel disease, and neuroinflammation.
Technical Specialist -CRISPR Screening in Neurodegeneration
Application closing date: 11 January 2026
You will perform large-scale phenotypic CRISPRn screens on human iPSC-derived microglia to identify modifiers of immune dysfunction relating to neurodegeneration, contributing to a unique, cross-comparative analysis integrating cellular models and patient-derived data.
(Senior) Postdoctoral Fellow - Computational Biology and Machine Learning
Application closing date: 1 February 2026
Join our interdisciplinary team at the forefront of computational biology and AI. Lead or contribute to transformative projects that integrate single-cell genomics, spatial transcriptomics, and generative AI to build next-generation models for understanding tissue biology and cellular dynamics across organs such as the pancreas, kidney, skin, and liver.
Available research focus areas include: space and multi-omics atlas construction, generative AI for cell fate and perturbations, foundational models for single-cell biology, Open Targets translational AI projects, agentic AI for scientific reasoning and experiment design, core machine learning research, multimodal learning, leap project.