Open Targets is based on the stunning Wellcome Genome Campus, home to some of the world's foremost institutes and organisations in genomics and computational biology. We work in dynamic teams at the interface of academic and pharma industry science on a crucial problem, how to be more successful in making drugs. Working with us, you will be exposed to new technologies and a dynamic set of scientists dedicated to translational research.
Our posts are usually in either one of our academic partners, The Wellcome Sanger Institute or EMBL-EBI and have terms and conditions associated with the employer.
Important note: applications may be reviewed on an ongoing basis and the advertised post(s) may be filled before the stated deadline.
This is a rolling advert. We will consider applications and hold interviews on an ongoing basis and the role will close when a successful appointment has been made.
Open Targets has launched Open Targets Genetics (https://genetics.opentargets.org), a portal that aggregates large scale GWAS data with functional genomics data to identify potential drug targets at disease and trait-associated loci.
An exciting Senior Computational Biologist / Computational Biologist (dependent upon experience) role funded by Open Targets has become available at the Wellcome Sanger Institute under the direction of Dr. Maya Ghoussaini. This is a unique opportunity for you to work with cutting-edge human genetics and functional genomics datasets and analyses and participate in the enhancement of the Open Targets Genetics Portal through the development of new functionality and features.
We are seeking an enthusiastic and motivated Technical Specialist (Senior Research Assistant) with immunology expertise to provide experimental, scientific and operational support to the Open Targets Validation Lab at the Wellcome Sanger Institute. Within the Open Targets Consortium, we run a number of projects focusing on diseases with inflammatory component. These projects generate lists of targets with new therapeutic potential, and the mission of the Validation Lab is to provide additional experimental evidence in support of the relevance of these targets in disease biology.
We are looking for a Project Manager to join Open Targets at EMBL-EBI. We are open to applicants at different career stages, but we are keen to find someone with the ability to catalyse a multidisciplinary project in the interface between science, drug discovery, and software development.
We are seeking to appoint an experienced Executive Administrator to provide support to a member of Sanger Faculty with a dual role of a Director of Experimental Sciences of Open Targets and a Group Leader in the Human Genetics Programme at the Wellcome Sanger Institute. In this role, you will provide administrative support, including diary, meeting arrangements and correspondence including drafting letters, emails or documents on behalf of the Director. Anticipate the needs of the Director and gauge opinion and influence thinking ahead of formal meetings to ensure well focused and productive discussions in support of effective decision making.
Applications are invited for a 3-year Postdoctoral Fellowship within the Genomics of Inflammation and Immunity group at the Wellcome Sanger Institute (WSI), headed by Dr. Carl Anderson. We are a multidisciplinary team consisting of statistical geneticists, molecular biologists, bioinformaticians, computer scientists and clinicians. We generate large-scale genetic and genomic datasets to understand the biological basis of inflammatory bowel disease (IBD). The translational aims of our research are to identify novel candidate drug targets and catalyse personalised medicine for IBD. There is a strong emphasis on personal development and career progression within the team.
We are seeking an enthusiastic and motivated postdoc with strong immunology background to join our interdisciplinary team on an exiciting project that will use cutting-edge techniques to study how genes associated with immune diseases modulate immune cell functions. Specifically, we aim to focus on B cell biology and using pooled CRISPR screens assess the effects of gene perturbations on disease relevant phenotypes. The strongest hits from the screens will be followed up using high throughput image-based cellular assays coupled with single-cell transcriptional readouts.
We are seeking two enthusiastic and motivated postdocs to join an interdisciplinary team on an exciting new project using cutting-edge techniques to study how genes associated with immune diseases modulate immune cell functions. We will perform pooled CRISPR screens in CD4 T and CD8 T cells to assess the effects of gene perturbations on disease relevant phenotypes. The most interesting hits will be validation of using high throughput image-based cellular assays coupled with transcriptional readouts.
A postdoctoral position is now available under the leadership of Dr Ana Cvejic (Wellcome Sanger Institute) as part of the Open Targets program.
In this project, you will analyse newly generated single cell (scRNA-Seq and scATAC-Seq) as well as novel and spatial transcriptomics data sets (In Situ Sequencing and 10x visium) to understand the molecular properties of immune cells infiltrating tumour sites. The underlying data sets comprise thousands of unique molecular signals measured for tens of thousands of cells or physical locations in each tumour. You will employ methods from high dimensional and spatial statistics to chart and understand the nature of different tumour-associated immune cells, how they interact and change biological functions and how the underlying molecular changes could be exploited as therapeutic targets.