14 December 2021Open Targets Platform 21.11 has been released!
29 November 2021Open Targets Genetics: Version 6 is out!
25 November 2021From genomes to medicines: an interview with Ian Dunham
14 October 2021Open Targets Platform 21.09 has been released!
30 September 2021Off the beaten path: combining genetic and small molecule approaches to validate novel drug targets
16 September 2021
David Gray of the Dundee Drug Discovery Unit shares three key pieces of advice from his career, through the story of the PCLX-001 molecule.Building the eQTL Catalogue: a Q&A with Kaur Alasoo
7 September 2021
Kaur Alasoo explains how the eQTL Catalogue came together, and what their future plans are. The eQTL Catalogue is the largest compendium of uniformly processed eQTL summary statistics and fine-mapping results.Summer School: A Crash Course in Open Targets, Part 3
3 August 2021
Clare West navigates the data downloads for the Open Targets Platform and Genetics portal, showing you how to access and query the data using Spark.Summer School: A Crash Course in Open Targets, Part 2
22 July 2021
Clare West guides you through the data available in the Open Targets informatics tools, with particular focus on the Genetics Portal.The PROTACtable genome: a systematic assessment of drug target tractability
21 July 2021
An Open Targets project has created a framework to assess whether human proteins could be targeted using Proteolysis Targeting Chimeras (PROTACs).Summer School: A Crash Course in Open Targets, Part 1
15 July 2021
Clare West guides you through how to access data from the Open Targets Platform and Genetics Portal using the web interface and GraphQL APIOpen Targets Genetics: Version 5 is out!
30 June 2021Open Targets Platform 21.06 has been released!
30 June 2021Building the Open Targets Platform Interface using React
3 June 2021
Cinzia Malangone, Jarrod Baker
27 May 2021
The next-generation Platform involved a switch from REST to a GraphQL API. Here we discuss the technology used, including Elasticsearch and Clickhouse.Wheat from the chaff: extracting, transforming, and loading data for Open Targets
Jarrod Baker, Cinzia Malangone
20 May 2021
The Open Targets Platform features a new ETL pipeline, written in Scala and Spark. Here we detail the purpose of the pipeline, and the technology it is based on.Towards a reproducible ETL: an overview of Open Targets' platform inputs
Cinzia Malangone, Jarrod Baker
13 May 2021
A discussion of how Platform Input support ensures reproducible inputs for our Extract-Transform-Load (ETL) pipeline.Beyond associations: building therapeutic hypotheses with Open Targets
Ian Dunham, David Hulcoop
6 May 2021
Open Targets directors describe the elements of a full therapeutic hypothesis, and how Open Targets is working to enable the systematic assessment of such hypotheses.The next-generation Open Targets Platform: rebuilt, redesigned, reimagined
29 April 2021
The next-gen Platform presents an improved user experience. It has been rebuilt with leading-edge technologies including Scala, Spark, and React, and includes new features and data.How we improved our experimental data curation during the COVID-19 lockdown
22 April 2021
Thanks to the expertise of our lab-based research colleagues, we made valuable contributions to our target validation projects in neurodegeneration and immunology & immflammation.