Open Targets is an innovative, large-scale, multi-year, public-private partnership that uses human genetics and genomics data for systematic drug target identification and prioritisation.

Visit the Open Targets Platform which integrates public domain data to enable target identification and prioritisation, or the Open Targets Genetics portal which identifies targets based on GWAS and functional genomics. We complement data integration with large scale systematic experimental approaches to support target identification, prioritisation and validation. Check out our latest papers describing our experimental target identification approaches in oncology, neurodegeneration, and immunity and inflammation.


News

Study tracking T-cell activation over time boosts search for immune disease treatments

26 May 2022

In a first-of-its-kind experiment, researchers have identified links between 127 genes and immune diseases, providing newfound insights into the sequence and timing of gene activity during the activation of T cells, a key process in regulating the body’s immune response.

The study, led by researchers from Open Targets, the Wellcome Sanger Institute and GSK, is published today (26 May 2022) in Nature Genetics. The result of a 3 year research effort, it is the first to show that nume...

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Our Partners

At the heart of Open Targets is a consortium of complementary partner institutions that bring their respective expertise to collaborative projects that improve how we systematically identify and prioritise drug targets.


Our Principles

A systematic approach

Systematically identify and prioritise the best targets to safely and effectively treat rare and common diseases

Rapid publication

We are committed to rapid publication and making data, methods and results publicly available as soon as possible

Open collaboration

We believe in non-exclusive partnerships that foster the free exchange of ideas, expertise, and data


Follow Us


Open Targets Platform 22.09 has been released

Sir Target

3 October 2022

Open Targets Platform 22.06 has been released!

Sir Target

24 June 2022

Next steps in our web applications' architecture

Carlos Cruz

21 June 2022

How Lorenzo Bomba is using rare genetic variants to understand blood metabolites

Helena Cornu

31 May 2022

Open Targets Platform 22.04 has been released!

Sir Target

28 April 2022

How we overhauled our literature processing pipeline using Named Entity Recognition

Miguel Carmona, Helena Cornu

19 April 2022

Open Targets Platform 22.02 has been released!

Sir Target

1 March 2022

Open Targets Genetics: version 7 is out!

Sir Target

25 February 2022

How Nuria Lopez-Bigas is untangling the genetics of cancer

Helena Cornu

4 February 2022

Untangling the genetics of neuroinflammation: an interview with Yixi Chen

Helena Cornu

14 December 2021

Open Targets Platform 21.11 has been released!

Sir Target

29 November 2021

Open Targets Genetics: Version 6 is out!

Sir Target

25 November 2021

From genomes to medicines: an interview with Ian Dunham

Helena Cornu

14 October 2021

Open Targets Platform 21.09 has been released!

Sir Target

30 September 2021

Off the beaten path: combining genetic and small molecule approaches to validate novel drug targets

Helena Cornu

16 September 2021

David Gray of the Dundee Drug Discovery Unit shares three key pieces of advice from his career, through the story of the PCLX-001 molecule.

Building the eQTL Catalogue: a Q&A with Kaur Alasoo

Helena Cornu

7 September 2021

Kaur Alasoo explains how the eQTL Catalogue came together, and what their future plans are. The eQTL Catalogue is the largest compendium of uniformly processed eQTL summary statistics and fine-mapping results.

Summer School: A Crash Course in Open Targets, Part 3

Clare West

3 August 2021

Clare West navigates the data downloads for the Open Targets Platform and Genetics portal, showing you how to access and query the data using Spark.

Summer School: A Crash Course in Open Targets, Part 2

Clare West

22 July 2021

Clare West guides you through the data available in the Open Targets informatics tools, with particular focus on the Genetics Portal.

The PROTACtable genome: a systematic assessment of drug target tractability

Helena Cornu

21 July 2021

An Open Targets project has created a framework to assess whether human proteins could be targeted using Proteolysis Targeting Chimeras (PROTACs).

Summer School: A Crash Course in Open Targets, Part 1

Clare West

15 July 2021

Clare West guides you through how to access data from the Open Targets Platform and Genetics Portal using the web interface and GraphQL API