Helena Cornu
14 October 2021
Open Targets Platform 21.09 has been released!Open Targets Outreach
30 September 2021
Off the beaten path: combining genetic and small molecule approaches to validate novel drug targetsHelena Cornu
16 September 2021
David Gray of the Dundee Drug Discovery Unit shares three key pieces of advice from his career, through the story of the PCLX-001 molecule.
Building the eQTL Catalogue: a Q&A with Kaur AlasooHelena Cornu
7 September 2021
Kaur Alasoo explains how the eQTL Catalogue came together, and what their future plans are. The eQTL Catalogue is the largest compendium of uniformly processed eQTL summary statistics and fine-mapping results.
Summer School: A Crash Course in Open Targets, Part 3Clare West
3 August 2021
Clare West navigates the data downloads for the Open Targets Platform and Genetics portal, showing you how to access and query the data using Spark.
Summer School: A Crash Course in Open Targets, Part 2Clare West
22 July 2021
Clare West guides you through the data available in the Open Targets informatics tools, with particular focus on the Genetics Portal.
The PROTACtable genome: a systematic assessment of drug target tractabilityHelena Cornu
21 July 2021
An Open Targets project has created a framework to assess whether human proteins could be targeted using Proteolysis Targeting Chimeras (PROTACs).
Summer School: A Crash Course in Open Targets, Part 1Clare West
15 July 2021
Clare West guides you through how to access data from the Open Targets Platform and Genetics Portal using the web interface and GraphQL API
Open Targets Genetics: Version 5 is out!Open Targets Outreach
30 June 2021
Open Targets Platform 21.06 has been released!Open Targets Outreach
30 June 2021
Building the Open Targets Platform Interface using ReactAlfredo Miranda
3 June 2021
The Open Targets Platform's user interface uses React and JavaScript to present the data produced by the ETL and served through the API.
Presenting Open Targets to the World via Play, Elasticsearch, Clickhouse and GraphQLCinzia Malangone, Jarrod Baker
27 May 2021
The next-generation Platform involved a switch from REST to a GraphQL API. Here we discuss the technology used, including Elasticsearch and Clickhouse.
Wheat from the chaff: extracting, transforming, and loading data for Open TargetsJarrod Baker, Cinzia Malangone
20 May 2021
The Open Targets Platform features a new ETL pipeline, written in Scala and Spark. Here we detail the purpose of the pipeline, and the technology it is based on.
Towards a reproducible ETL: an overview of Open Targets' platform inputsCinzia Malangone, Jarrod Baker
13 May 2021
A discussion of how Platform Input support ensures reproducible inputs for our Extract-Transform-Load (ETL) pipeline.
Beyond associations: building therapeutic hypotheses with Open TargetsIan Dunham, David Hulcoop
6 May 2021
Open Targets directors describe the elements of a full therapeutic hypothesis, and how Open Targets is working to enable the systematic assessment of such hypotheses.
The next-generation Open Targets Platform: rebuilt, redesigned, reimaginedHelena Cornu
29 April 2021
The next-gen Platform presents an improved user experience. It has been rebuilt with leading-edge technologies including Scala, Spark, and React, and includes new features and data.
How we improved our experimental data curation during the COVID-19 lockdownPanos Zalmas
22 April 2021
Thanks to the expertise of our lab-based research colleagues, we made valuable contributions to our target validation projects in neurodegeneration and immunology & immflammation.
Q&A with Babatomiwa Adebiyi, an intern with the Open Targets PlatformHelena Cornu, David Ochoa
16 April 2021
Babatomiwa Adebiyi is a computer science student at MIT. He tell us about his machine learning project to prioritise targets in our main therapeutic areas: cancer, immune diseases, and neurological diseases
Job seeking during the pandemic: a Q&A with Kostas TsirigosKostas Tsirigos
26 March 2021
How do you prepare for a virtual interview? What is the remote onboarding process like? Open Targets project manager Kostas Tsirigos tells us about his experience.
Open Targets hosts Kiran Musunuru: insights into the genetic basis of coronary heart diseaseHelena Cornu
16 March 2021
An insight into Kiran Musunuru's career, from identifying mutations in ANGPTL3 that protect against heart disease, to working on a "vaccination" against heart attacks, and more.