Open Targets is an innovative, large-scale, multi-year, public-private partnership that uses human genetics and genomics data for systematic drug target identification and prioritisation.

Visit the Open Targets Platform which integrates public domain data to enable target identification and prioritisation, or Open Targets Genetics which identifies targets based on GWAS and functional genomics. We complement data integration with large scale systematic experimental approaches to support target identification, prioritisation and validation. Check out our latest papers describing our experimental target identification approaches in oncology, neurodegeneration, and immunity and inflammation.


News

Researchers decipher mechanisms of liver regeneration

23 May 2024

Scientists from the Berlin Institute of Health at Charité (BIH) and Open Targets together with colleagues from the University of Cambridge, and Addenbrooke’s Hospital in Cambridge, UK, uncovered mechanisms driving regeneration of the liver during chronic liver disease. This regenerative process allows the liver to repair itself when chronically injured but could also result in progression toward cancer. The researchers were able to demonstrate this first by performing single-cell a...

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Our Partners

At the heart of Open Targets is a consortium of complementary partner institutions that bring their respective expertise to collaborative projects that improve how we systematically identify and prioritise drug targets.


Our Principles

A systematic approach

Systematically identify and prioritise the best targets to safely and effectively treat rare and common diseases

Rapid publication

We are committed to rapid publication and making data, methods and results publicly available as soon as possible

Open collaboration

We believe in non-exclusive partnerships that foster the free exchange of ideas, expertise, and data


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Integrating pharmacogenetics data: a new lens for target prioritisation

Irene López Santiago, April Shen

9 May 2024

Open Targets Platform 24.03 has been released!

Sir Target

20 March 2024

Q&A with Lucy Sibbring, an intern with the Open Targets data team

Helena Cornu

29 February 2024

Open Targets Platform 23.12 has been released!

Sir Target

30 November 2023

Q&A with Jason Menkiti, an intern with the Open Targets data team

Helena Cornu

8 November 2023

Case study: NCI’s Molecular Targets Platform

Annalisa Buniello

31 October 2023

Case study: Extracting tidy data from Open Targets Genetics with Otargen

Helena Cornu

24 October 2023

Open Targets Platform 23.09 has been released!

Sir Target

21 September 2023

Welcome to new Director David Hulcoop

Helena Cornu

21 September 2023

From hibernation to neurodegeneration: how a cold-resistance protein is paving the way to dementia treatments

Helena Cornu

15 August 2023

Meet Yakov Tsepilov, our new Genetics team leader

Helena Cornu

7 August 2023

Open Targets Platform 23.06 has been released!

Sir Target

26 June 2023

Case study: Open Targets at your fingertips with Raycast

Helena Cornu, Irene López Santiago

20 June 2023

Case study: Querying the Open Targets Platform using natural language

Helena Cornu

25 May 2023

Code breaking and the Human Genome Project

Ian Dunham

25 April 2023

A leading scientist in the sequencing of the human genome, Ian Dunham reflects on the early years of the Wellcome Sanger Institute.

How Emmanouil Metzakopian is finding gene targets to treat neurodegeneration

Helena Cornu

5 April 2023

Manos Metzakopian discusses his latest research, in which the team validated KAT2B gene knockouts as neuroprotective against ER stress.

Provenance Metadata — towards reproducible research

Manuel Bernal Llinares

22 March 2023

How the Open Targets Platform Integrates Gene Burden Analyses

Irene López Santiago

6 March 2023

Analysis and explanation of gene burden associations in the Open Targets Platform

Open Targets Platform 23.02 has been released!

Sir Target

22 February 2023

How Open Targets is using Artificial Intelligence and Machine Learning to identify and prioritise drug targets

Helena Cornu

2 December 2022