Please note that some applications will be reviewed on an ongoing basis and the advertised post(s) may be filled before the stated deadline.


Computational Biologist/Bioinformatician

A Wellcome Sanger Institute contract - closing date: 25 May 2019

A Computational Biologist/Bioinformatician role funded by Open Targets, is available at the Wellcome Sanger Institute in a new team under the leadership of Dr. Maya Ghoussaini. This is an exciting opportunity for you to participate in the enhancement of the existing Open Targets Genetics through the development of new functionality and features.

You will have the opportunity to work across a range of analysis such as:

  • Integrate genetic and cell-specific genomic data to identify and validate casual links between targets and diseases and improve the Genetics Portal
  • Perform association analysis on UK Biobank data with a particular focus on therapeutic areas important for Open Targets
  • Work together with other members of the Open Targets team on statistical genetics analysis for large scale sequence analysis

You will also have the opportunity to interact with active computational and experimental research teams using cutting edge genomic techniques. [read more]


Research Associate (Fixed Term)

A University of Cambridge contract - closing date: 26 May 2019

We are looking for a post-doctoral researcher to join the research team of Prof. Ludovic Vallier at The Wellcome Trust - Medical Research Council Cambridge Stem Cell Institute. The Vallier lab studies the mechanisms controlling human pluripotent stem cells (hPSCs) differentiation to generate cell types with a clinical interest for disease modelling and cell-based therapies.

The postholder will explore the molecular mechanisms controlling lipid accumulation, lipid toxicity, inflammation and fibrosis in NAFLD using a 3D culture system mimicking the architecture of the liver aiming to identify new targets genes for drug development. [read more]


Research Assistant (Fixed Term)

A University of Cambridge contract - closing date: 26 May 2019

We are looking to recruit a research assistant to join the research team of Prof Ludovic Vallier.

The post holder will be involved in a project aiming to explore the molecular mechanisms controlling lipid accumulation, lipid toxicity, inflammation and fibrosis in NAFLD using a 3D culture system mimicking the architecture of the liver. For that, the postholder will genetically modify hPSCs to knock out genes associated with NAFLD progression. The resulting cell lines will be then differentiated into a diversity of cell types including hepatocytes and cholangiocytes. The function of candidate genes will be studied in vitro using hPSCs. Techniques anticipated to be used include hPSCs culture and differentiation, CRISPR directed mutagenesis, and metabolic assays. Homepage: [read more]


Protein Computational Scientist

An EMBL-EBI contract - closing date: 26 May 2019

An exciting opportunity has been created for a talented scientist to work on methods to assess and quantify the tractability (also known as “druggability” or “ligandability”) of potential new targets for drug discovery. Reporting to the ChEMBL team leader, you will develop, assess and validate methods for quantifying target tractability with the ultimate goal of incorporating such methodologies into the Open Targets Platform building upon and extending our current algorithms. We now wish to develop new approaches based on protein structure and sequence, exploit the full spectrum of drug discovery data in ChEMBL and explore new modalities beyond the current small molecule and antibody pipelines. As part of the EU Horizon 2020 EOSC-Life project, you will work with collaborators across Europe to deliver pipelines that integrate data and computational methods in cloud-based environments. [read more]


Postdoctoral Fellow - Computational

A Wellcome Sanger Institute contract - closing date: 2 June 2019

A postdoctoral position is available at the Wellcome Sanger Institute to combine state-of-the-art single-cell experimental data generation with computational analysis using novel methods to reveal the full spectrum of transcriptional and epigenetic changes that are associated with myeloid progenitors’ migration and differentiation at the tumour sites. You will have a PhD in Bioinformatics, Computational Biology, Biostatistics or in a related quantitative field (e.g. Mathematics, Physics, Statistics). [read more]


Postdoctoral Fellow - Experimental Data Generation

A Wellcome Sanger Institute contract - closing date: 2 June 2019

A position is now available for a highly motivated Postdoctoral Fellow to join the Wellcome Sanger Institute in collaboration with Open Targets. You will have a PhD with significant experience in molecular and cell biology. Experience in CRISPR screening will be highly desirable. Knowledge or interest in the field of haematology, cancer biology and inflammation would be highly advantageous. You will be able to demonstrate independent, critical thinking, will be passionate about science, and keen to learn and improve skills in an outstanding research environment. [read more]


Advanced Research Assistant

A Wellcome Sanger Institute contract - closing date: 2 June 2019

We are seeking an enthusiastic Advanced Research Assistant to join the Wellcome Sanger Institute and other Open Targets partners. You will carry out both routine and more bespoke laboratory protocols and procedures on the regulation of haematopoiesis in homeostasis and disease. Excellent verbal and email communication is essential to keep both the team and senior staff fully appraised of progress. [read more]


Postdoctoral Fellow - Cancer Drug Combinations

A Wellcome Sanger Institute contract - closing date: 9 June 2019

A position is now available for a computational postdoctoral scientist to use CRISPR-Cas9 screening to identify combination targets for cancer. You will develop analytical and statistical approaches to model gene-gene interactions using large-scale CRISPR screening datasets, and combine these results with genomic, transcriptomic and proteomic datasets. [read more]


Computational Postdoctoral Fellow - Cancer Drug Combinations

A Wellcome Sanger Institute contract - closing date: 9 June 2019

A postdoctoral position is available at the Wellcome Sanger Institute to develop dual-knockout CRISPR-based screening approaches and lead efforts to experimentally evaluate combination targets for cancer. You will analyse large-scale CRISPR screening in cancer cell lines to identify and investigate new combination therapies, aiming at inhibiting multiple targets or cancer pathways to combat resistance and exploit new actionable dependencies in defined genetic contexts. [read more]


Postdoctoral Fellow - Tumour Cell Immune Response CRISPR

A Wellcome Sanger Institute contract - closing date: 9 June 2019

We are seeking a talented postdoctoral scientist to develop CRISPR base-editing screens in cancer cells to characterise regulation of tumour cell mediated immune signaling to understand mechanisms of resistance to checkpoint therapies. You will work as part of multidisciplinary and collaborative team within Open Targets and in collaboration with the Netherlands Cancer Institute. [read more]


Postdoctoral Fellow

An EMBL-EBI contract - closing date: 13 June 2019

A position is now available for a postdoctoral fellow to join our collaborative team to unlock the potential of rational target/pathway combinations in oncology through integrative network biology and large-scale functional genomics screens. You will handle very large and diverse omics datasets, from genomics to phosphoproteomics, as well as CRIPSR perturbation data. [read more]


Imaging Mass Spectrometrist

An EMBL-EBI contract - closing date: 7 July 2019

The European Molecular Biology Laboratory (EMBL) in Heidelberg is looking for an a university graduate with a degree in Analytical Chemistry (or related disciplines) to apply MALDI-imaging mass spectrometry methods to investigate metabolites, small molecules and/or lipids in immune human cells. [read more]