The Open Targets team at our 5 year anniversary celebration in June 2019

Join our team!

Open Targets is based on the stunning Wellcome Genome Campus, home to some of the world's foremost institutes and organisations in genomics and computational biology. We work in dynamic teams at the interface of academic and pharma industry science on a crucial problem, how to be more successful in making drugs. Working with us, you will be exposed to new technologies and a dynamic set of scientists dedicated to translational research.

Our posts are usually in either one of our academic partners, The Wellcome Sanger Institute or EMBL-EBI and have terms and conditions associated with the employer.

Important note: applications may be reviewed on an ongoing basis and the advertised post(s) may be filled before the stated deadline.


Postdoctoral Fellow — CRISPR analysis of gene co-dependencies in cancer

Application closing date: 8 February 2023

We are looking for a Postdoctoral Fellow (PDF) to help deliver Project Symphony, an OpenTargets funded Project aiming to perform extensive combinatorial CRISPR screening of cancer cell lines at the Wellcome Sanger Institute. You will work closely with Dr. Kostas Tzelepis who is based at the University of Cambridge and an expert in CRISPR systems. This will be for a 3 year fixed term contract.

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Senior Bioinformatician

Application closing date: 15 February 2023

This is an exciting opportunity for you to participate in the enhancement of the Open Targets Genetics Portal through the development of new functionality and features using state of the art statistical genetics analysis.

You will actively engage in the integration of data from several genetic analyses including rare variant association analyses, burden tests in large-scale datasets such as the UK Biobank, and tissue enrichment analyses.

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Senior Staff Fellow — CRISPR analysis of gene co-dependencies in cancer

Application closing date: 15 February 2023

We are looking for an experienced Senior Staff Scientist to help deliver Project Symphony, an OpenTargets funded Project aiming to perform extensive combinatorial CRISPR screening of cancer cell lines at the Wellcome Sanger Institute. You will be joining the Experimental Cancer Genetics Group for a 3 year fixed term contract. In this project, we will use a combination of both established CRISPR/Cas9 technology and new CRISPR technologies with the aim of identifying genetic interactions and gaining mechanistic insights into the cellular effects of gene co-disruption.

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Computational Postdoctoral Fellow: CRISPR analysis of gene co-dependencies in cancer

Application closing date: 19 February 2023

We are looking for a Computational Postdoctoral Fellow to help deliver Project Symphony, an OpenTargets-funded Project aiming to perform extensive combinatorial CRISPR screening of cancer cell lines at the Wellcome Sanger Institute. This position will be for a 3-year fixed term contract. You will join the Experimental Cancer Genetics Team lead by David Adams.

In this project, we will use a combination of both established CRISPR/Cas9 technology and new CRISPR technologies with the aim of identifying genetic interactions and gaining mechanistic insights into the cellular effects of gene co-disruption.

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Postdoctoral Fellow - E3-Ligase mediated Protein Degradation in Cancer Cells

Application closing date: 23 February 2023

Targeted protein degradation is a promising area for development of innovative therapeutics. Working with Mathew Garnett, the position is at the cutting-edge of systems biology through combining CRISPR-based genetic screening to systematically assemble proteomic maps of E3 ligase substrates in cancer cells. You will work as part of multidisciplinary team from academia and industry to collaboratively generate and interpret large-scale proteomic datasets to map E3 target genes.

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Postdoctoral Fellow — Mucosal Immunology

Application closing date: 26 February 2023

We are looking for a Postdoctoral Fellow (PDF) with a background in mucosal immunology to lead the design, analysis, and interpretation of cellular genomics studies of inflammatory bowel disease. It is a 3-year fixed term fellowship within the Genomics of Inflammation and Immunity group at the Wellcome Sanger Institute (WSI), headed by Dr. Carl Anderson.

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Computational Postdoctoral Fellow-Single Cell Genomics of Inflammatory Bowel Disease

Application closing date: 26 February 2023

We are looking for a Computational Postdoctoral Fellow (PDF) to be responsible for the analysis of our large-scale single-cell genomics studies of inflammatory bowel disease. It is a 3-year fixed term fellowship within the Genomics of Inflammation and Immunity group at the Wellcome Sanger Institute, headed by Dr. Carl Anderson.

You will lead the analysis of a large single-cell genomics study aimed at elucidating the cellular and molecular mechanisms underpinning IBD susceptibility. We are generating single-cell RNA and/or ATAC sequencing data from gut biopsies and blood samples ascertained from hundreds of IBD patients and non-IBD controls. Data is already available for around 200 individuals, with more being generated over the next four years. You will use these data to identify genes, pathways and cell-types associated with IBD susceptibility, progression and drug response.

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